Abstract #1457
19 F/ 1 H MR Molecular Imaging Following Anti-angiogenic Therapy in a Translatable Preclinical Asthma Model
Anne Schmieder 1 , Jochen Keupp 2 , Huiying Zhang 1 , Todd Williams 1 , John Stacy Allen 1 , Xiaoxia Yang 1 , Erik Storrs 1 , Krishna Paranandi 1 , Elizabeth Wagner 3 , and Gregory Lanza 1
1
Washington University Medical School, St
Louis, MO, United States,
2
Philips
Research Europe, Hamburg, Germany,
3
Johns
Hopkins School of Medicine, Baltimore, MD, United States
A progressive approach to asthma therapy may be to
target bronchial angiogenesis in an attempt to improve
pulmonary function. We have recently used high
resolution, dual 19F/1H MR molecular imaging (3T) for
quantifying angiogenesis in rat asthma model. Expanding
on this, we used this method to noninvasively quantify
the early effect of targeted antiangiogenic therapy on
pulmonary neovascularization in asthma. We observed
greatly diminished 19F lung signal after treatment with
novel prodrug micelles, reflective of a decrease in
neovascularization. This is a clinically translatable
approach for noninvasive evaluation and optimization of
antiangiogenic therapy in chronic airway inflammation.
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