Dual echo, PDFF and mDIXON compared to 1 H-MRS for fat fraction estimation: only PDFF can accurately measure low fat fractions.
Jurgen Henk Runge 1 , Ulrich H Beuers 2 , Aart J Nederveen 1 , and Jaap Stoker 1
Radiology, Academic Medical Center,
Amsterdam, Noord-Holland, Netherlands,
& Hepatology, Academic Medical Center, Amsterdam,
Accurate and reproducible liver fat fraction (FF)
estimation is important.
is the MR reference standard but has certain drawbacks,
some of which are resolved by imaging-based FF
estimation. The standard mDIXON acquisition allows
high-resolution water (W) and (F) image reconstruction,
but its FA and short TR, induce
causing over-estimation of low FF. We compared dual
echo, mDIXON and proton density fat fraction (PDFF) with
in fatty liver disease patients. mDIXON had non-zero
lower limit, i.e. over-estimation of low FF: standard
mDIXON images should not be used for FF mapping. PDFF
compared best to
and is preferable.
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