Intravoxel incoherent motion diffusion-weighted imaging and texture heterogeneity for staging of hepatic fibrosis in children

Diffusion weighted imaging (DWI) has been used to assess liver fibrosis by mean apparent diffusion coefficient values in liver parenchyma. However, fibrotic distribution in the liver is progressive and uneven, and the ADC value can be influenced by true molecular diffusion in a solid tissue and microcirculation in vessels , which limit the general utility of conventional DWI. With the advent of intravoxel incoherent motion (IVIM) mode, perfusion-related diffusivity and pure molecular diffusivity could be generalized simultaneously. We therefore assessed performance of IVIM DWI parameters and corresponding coefficients of variation (CVs) for liver fibrotic staging and texture heterogeneity analysis in children.

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