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Abstract #1526

Simultaneous Acquisition Sequence for High Accuracy Whole Liver Perfusion Quantification(SAHA)

Jia Ning 1 , Bida Zhang 2 , Honsum Li 1 , Dan Zhu 1 , Feng Huang 2 , Shuo Chen 1 , Peter Koken 3 , Jouke Smink 4 , and Huijun Chen 1

1 Center for Biomedical Imaging Research, Biomedical Engineering, School of Medicine, Tsinghua University, Beijing, China, 2 Philips Research China, Beijing, China, 3 Innovative Technologies, Research Laboratories, Philips Technologie GmbH, Hamburg, Germany, 4 Philips Healthcare, MR Clinical Science, Best, Netherlands

Dynamic contrasted enhanced (DCE) MR imaging combined with pharmacokinetic modeling, which can quantify the perfusion and permeability of capillary in liver, is an important technique in diagnosis for malignancy detection, fibrosis stage estimation and hepatic function evaluation [1]. DCE-MRI of liver requires high temporal resolution for accurate arterial input function (AIF) and portal venous input function (VIF). On the other hand, high spatial resolution is also important small lesion detection. However, it is hard to achieve both high temporal resolution and spatial resolution at the same time with enough SNR and coverage for whole liver imaging. In this study, considering the AIF&VIF are fast changing while the intensity of hepatic parenchyma is slowly evolved, we propose a new DCE acquisition method to acquire two 2D acquisitions for high temporal resolution AIF and VIF, and a 3D acquisition for high spatial resolution whole liver imaging, simultaneously. In this interleaved acquisition scheme, the proposed sequence can improve the accuracy of pharmacokinetic analysis.

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