Abstract #1528
Hypoenhancing liver lesion on both portovenous and delayed phase gadobutrol and gadofosveset-enhanced MRI as a sign of malignancy in the diagnosis of colorectal liver metastases (CRLM)
Helen Cheung 1 , Paul Karanicolas 2 , Chirag Patel 1 , Natalie Coburn 2 , Masoom A Haider 1 , Calvin Law 2 , and Laurent Milot 1
1
Medical Imaging, Sunnybrook Health Sciences
Centre, Toronto, ON, Canada,
2
Surgery,
Sunnybrook Health Sciences Centre, Toronto, Ontario,
Canada
Accurate diagnosis of colorectal liver metastases (CRLM)
is a common and important clinical problem. Classically,
CRLM appear hypoenhancing on portovenous and delayed
phases with dynamic contrast enhanced MRI using
extracellular contrast agents (eg. gadobutrol). These
CRLM tend to be easy to diagnose because benign lesions
rarely demonstrate this sign. However, some CRLM will
not follow this pattern and can be difficult to
diagnose. We hypothesize that more lesions will
demonstrate this sign with intravascular contrast agents
(eg. gadofosveset) leading to improved diagnosis. With
gadofosveset, 26% more lesions demonstrated this sign
than with gadobutrol, resulting in improved sensitivity
(65% to 90%).
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