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Abstract #1532

Correlation of histological and IVIM-derived measures of vascularity in hypo- and hypervascularized pancreatic lesions

Miriam Klauss 1 , Philipp Mayer 1 , Klaus Maier-Hein 2 , Frank Bergmann 3 , Thilo Hackert 4 , Lars Grenacher 1 , and Bram Stieltjes 5

1 Diagnostic and Interventional Radiology, University hospital Heidelberg, Heidelberg, Baden-Wrttemberg, Germany, 2 DKFZ, Heidelberg, Baden-Wrttemberg, Germany, 3 Pathology, University of Heidelberg, Baden-Wrttemberg, Germany, 4 Surgery, University hospital Heidelberg, Baden-Wrttemberg, Germany, 5 Radiology, University hospital Basel, Basel, Switzerland

This study evaluated the correlation between IVIM-derived parameters and histologically determined vascular density (MVD) in hypo- and hypervascular solid pancreatic carcinomas. 42 patients underwent DWI-MRI with eight b-values. IVIM-parameters were extracted from VOIs, MVD was determined histologically and Pearson-correlation-coefficients were calculated between the parameters. f and MVD showed excellent correlation (r=0.85), D and D* did not correlate. This is the first study showing a histological correlation between the IVIM-derived perfusion fraction f and the microvessel density in hypo- and hypervascular solid pancreatic tumors. Therefore, IVIM DWI imaging may serve as noninvasive marker of tumor vascularity in pancreatic cancer.

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