Abstract #1532
Correlation of histological and IVIM-derived measures of vascularity in hypo- and hypervascularized pancreatic lesions
Miriam Klauss 1 , Philipp Mayer 1 , Klaus Maier-Hein 2 , Frank Bergmann 3 , Thilo Hackert 4 , Lars Grenacher 1 , and Bram Stieltjes 5
1
Diagnostic and Interventional Radiology,
University hospital Heidelberg, Heidelberg,
Baden-Wrttemberg, Germany,
2
DKFZ,
Heidelberg, Baden-Wrttemberg, Germany,
3
Pathology,
University of Heidelberg, Baden-Wrttemberg, Germany,
4
Surgery,
University hospital Heidelberg, Baden-Wrttemberg,
Germany,
5
Radiology,
University hospital Basel, Basel, Switzerland
This study evaluated the correlation between
IVIM-derived parameters and histologically determined
vascular density (MVD) in hypo- and hypervascular solid
pancreatic carcinomas. 42 patients underwent DWI-MRI
with eight b-values. IVIM-parameters were extracted from
VOIs, MVD was determined histologically and
Pearson-correlation-coefficients were calculated between
the parameters. f and MVD showed excellent correlation
(r=0.85), D and D* did not correlate. This is the first
study showing a histological correlation between the
IVIM-derived perfusion fraction f and the microvessel
density in hypo- and hypervascular solid pancreatic
tumors. Therefore, IVIM DWI imaging may serve as
noninvasive marker of tumor vascularity in pancreatic
cancer.
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