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Abstract #1537

Aortic Pulse Wave Velocity Measured using4D-Flow MRI in Patients with Portal Hypertension

Matthew R. Smith 1 , Alejandro Roldan-Alzate 1 , Oliver Wieben 1,2 , Scott B. Reeder 1,2 , and Christopher J. Francois 1

1 Radiology, University of Wisconsin, Madison, WI, United States, 2 Medical Physics, University of Wisconsin, Madison, WI, United States

Diffuse liver disease, such as non-alcoholic fatty liver disease (NAFLD), causes a generalizedpro-inflammatory response that leads to increased risk of cardiovascular disease. Aortic pulse wave velocity (PWV) is a biomarker of vascular stiffeningthat can indicate increased cardiovascular risk.We therefore hypothesized that aortic PWV would be elevated in the setting of cirrhosis and portal hypertension. 4D flow MRI was performed at 3T in 11 patients with portal hypertension and 13 healthy controls. Aortic PWV was calculated using the time-to-foot (TTF) method and demonstrated statistically significant differences between the two groups.

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