Abstract #1543
A novel non-invasive MRI tool for quantification of placental oxygen transport in vivo
Reut Avni 1 , Joel Garbow 2 , and Michal Neeman 1
1
Biological Regulation, Weizmann Institute of
Science, Rehovot, Israel,
2
Biomedical
MR laboratory, Mallinckrodt Institute of Radiology,
Washington University, St. Louis, Missouri, United
States
Oxygen transport, one of several key functions performed
by the placenta, depends primarily on placental oxygen
pressure gradient and the oxygen affinity of fetal and
maternal blood. We describe a novel, non-invasive MRI
method for deriving MRI-based oxygen-hemoglobin
dissociation curves. Pregnant ICR mice were analyzed
using a gradual respiration challenge from hyperoxia to
hypoxia. Apparent P50 (AP50) values, characteristic of
oxygen affinity, derived from the curves, demonstrate a
clear difference between adult and fetal tissues, as
well as changes throughout gestation. This approach to
probe and quantify oxygen transfer across the placenta
may be useful for evaluation of fetal health.
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