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Abstract #1567

High non-linear diffusion fraction correlates with histological fibrosis in allograft kidneys

General Leung 1,2 , Nan Jiang 3 , Anthony A Sheen 1 , Serge Jothy 4 , Darren A Yuen 2,5 , and Anish Kirpalani 1,2

1 Medical Imaging, St. Michael's Hospital, Toronto, Ontario, Canada, 2 Keenan Research Centre, St Michael's Hospital, University of Toronto, Toronto, Ontario, Canada, 3 Faculty of Medicine, University of Toronto, Toronto, Canada, 4 Department of Pathology, St. Michael's Hospital, Toronto, Ontario, Canada, 5 Division of Nephrology, St Michael's Hospital, Toronto, Ontario, Canada

The signal acquired in a diffusion weighted sequence has been shown to be sensitive to both perfusion and diffusion components. We sought to find the degree to which flow and microcirculation are present in transplant kidneys by measuring the non-linear fraction of the diffusion curve in 8 patients. We compared these results to histopathology of the biopsy specimen. We demonstrate an increased non-linear diffusion fraction in patients with pathologically proven fibrosis. Further investigation of the pathological specimens are warranted to verify these findings.

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