Abstract #1573
Metabolic Imaging of Renal Triglyceride Content: Validation by Porcine Kidney Biopsies
Paul de Heer 1 , Jacqueline T Jonker 2 , Evelien H van Rossenberg 2 , Marten A Engelse 2 , Trea CM Streefland 3 , Ton J Rabelink 2 , Andrew G Webb 1 , Patrick CN Rensen 3,4 , Hildo J Lamb 5 , and Aiko PJ de Vries 2
1
CJ Gorter Center for High Field MRI,
Radiology, Leiden University Medical Center, Leiden,
Netherlands,
2
Nephrology,
Leiden University Medical Center, Leiden, Netherlands,
3
Endocrinology,
Leiden University Medical Center, Leiden, Netherlands,
4
Einthoven
Laboratory for Experimental Vascular Medicine, Leiden,
Netherlands,
5
Radiology,
Leiden University Medical Center, Leiden, Netherlands
Obesity is an independent risk factor for development of
nephropathy. However, human studies have been limited,
because of the complication risk of repeated renal
biopsies. Therefore, we assessed the reproducibility of
the non-invasive 1H-MRS renal triglyceride (TG)
measurement, compared to TG content in kidney biopsies,
in an animal model. In total fourteen left-sided porcine
kidneys were obtained. The average TG level in the renal
cortex was 0.250.16% measured by 1H-MRS and 12675
nmol/mg protein in biopsy. The Pearson correlation
coefficient is 0.81 (p < 0.0001) showing good
correlation The Bland-Altman analysis shows a bias close
to zero confirming good correlation.
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