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Abstract #1575

Patients with high blood pressure should avoid aspirin: reduced renal perfusion in hypertensive EP4 knockout mice

Greg O Cron 1,2 , Jean-Franois Thibodeau 1,2 , Gerd Melkus 1,2 , Anthony Carter 2 , Ian G Cameron 1,2 , Nicola Schieda 1,2 , Wael Shabana 1,2 , and Chris Kennedy 1,2

1 Ottawa Hospital Research Institute, Ottawa, Ontario, Canada, 2 University of Ottawa, Ottawa, Ontario, Canada

Hypertension vasoconstricts kidney vessels while NSAIDs (e.g. aspirin) suppress EP-receptor compensatory vasodilation, thus making hypertension and NSAIDS a potentially dangerous combination. Direct, in-vivo evidence of this phenomenon is lacking, however. We used DCE-MRI to compare renal perfusion in hypertensive mice with and without normal EP4 recepters, with the hypothesis that EP4 knockout mice would suffer reduced renal perfusion. This hypothesis was confirmed: In mice with AngII-induced hypertension, suppression of the EP4 receptor led to a catastrophic reduction in renal perfusion. This supports the idea that NSAIDs are bad for hypertensive patients and hints that EP4-selective activation (pharmacologically) may be beneficial.

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