Abstract #1575
Patients with high blood pressure should avoid aspirin: reduced renal perfusion in hypertensive EP4 knockout mice
Greg O Cron 1,2 , Jean-Franois Thibodeau 1,2 , Gerd Melkus 1,2 , Anthony Carter 2 , Ian G Cameron 1,2 , Nicola Schieda 1,2 , Wael Shabana 1,2 , and Chris Kennedy 1,2
1
Ottawa Hospital Research Institute, Ottawa,
Ontario, Canada,
2
University
of Ottawa, Ottawa, Ontario, Canada
Hypertension vasoconstricts kidney vessels while NSAIDs
(e.g. aspirin) suppress EP-receptor compensatory
vasodilation, thus making hypertension and NSAIDS a
potentially dangerous combination. Direct, in-vivo
evidence of this phenomenon is lacking, however. We used
DCE-MRI to compare renal perfusion in hypertensive mice
with and without normal EP4 recepters, with the
hypothesis that EP4 knockout mice would suffer reduced
renal perfusion. This hypothesis was confirmed: In mice
with AngII-induced hypertension, suppression of the EP4
receptor led to a catastrophic reduction in renal
perfusion. This supports the idea that NSAIDs are bad
for hypertensive patients and hints that EP4-selective
activation (pharmacologically) may be beneficial.
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