Quantification and reproducibility of single kidney function using DCE-MRI in healthy subjects
Eli Eikefjord 1,2 , Erling Andersen 3 , Jan Ankar Monssen 1 , Erlend Hodneland 4 , Erik Hanson 5 , Arvid Lundervold 1,4 , and Jarle Rrvik 1,2
Radiology, Haukeland University Hospital,
Bergen, Hordaland, Norway,
Medicine, University of Bergen, Bergen, Hordaland,
Engineering, Haukeland University Hospital, Bergen,
University of Bergen, Hordaland, Norway,
University of Bergen, Hordaland, Norway
Documentation on reproducibilities in estimation of
renal functional parameters using DCE-MRI is limited.
Twenty healthy subjects being in a controlled
physiological state were examined twice with identical
3D SPGR DCE-MRI acquisition technique, aiming at
exploring intra-subject reproducibility and variability
in perfusion and filtration estimates. Within-subject
variation was 14-24% and estimates were reproduced with
good to excellent agreement between MR1 and MR2. Mean
difference in total GFR and renal blood flow between MR1
and MR2 was 3.5 ml/min and 43.7 ml/100ml/min,
respectively. Variance and agreement correspond to
expected levels accounting for normal physiological
variation and instances of quality impaired exams.
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