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Abstract #1578

Quantification and reproducibility of single kidney function using DCE-MRI in healthy subjects

Eli Eikefjord 1,2 , Erling Andersen 3 , Jan Ankar Monssen 1 , Erlend Hodneland 4 , Erik Hanson 5 , Arvid Lundervold 1,4 , and Jarle Rrvik 1,2

1 Radiology, Haukeland University Hospital, Bergen, Hordaland, Norway, 2 Clinical Medicine, University of Bergen, Bergen, Hordaland, Norway, 3 Clinical Engineering, Haukeland University Hospital, Bergen, Hordaland, Norway, 4 Biomedicine, University of Bergen, Hordaland, Norway, 5 Mathematics, University of Bergen, Hordaland, Norway

Documentation on reproducibilities in estimation of renal functional parameters using DCE-MRI is limited. Twenty healthy subjects being in a controlled physiological state were examined twice with identical 3D SPGR DCE-MRI acquisition technique, aiming at exploring intra-subject reproducibility and variability in perfusion and filtration estimates. Within-subject variation was 14-24% and estimates were reproduced with good to excellent agreement between MR1 and MR2. Mean difference in total GFR and renal blood flow between MR1 and MR2 was 3.5 ml/min and 43.7 ml/100ml/min, respectively. Variance and agreement correspond to expected levels accounting for normal physiological variation and instances of quality impaired exams.

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