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Abstract #1587

Radioembolization dosimetry using gadoxetate disodium for segmentation of the healthy liver parenchyma

Hanke J Schalkx 1 , Jip P Prince 1 , Gerrit H van de Maat 2 , Peter R Seevinck 3 , Clemens Bos 3 , Wouter B Veldhuis 1 , Maarten S van Leeuwen 1 , Maurice AAJ van den Bosch 1 , Marnix GEH Lam 1 , and Marijn van Stralen 3

1 Radiology and Nuclear Medicine, University Medical Center Utrecht, Utrecht, Utrecht, Netherlands, 2 Quirem Medical BV, Diepenveen, Netherlands, 3 Image Sciences Institute, University Medical Center Utrecht, Utrecht, Utrecht, Netherlands

In intra-arterial radioembolization for the treatment of non-resectable liver cancer, the amount of injected activity is limited by its effect on the healthy parenchyma. Therefore, it is essential that the healthy parenchymal volume is measured accurately. In a holmium-treated patient population, the role of gadoxetate-enhanced MRI was investigated. Automatic segmentation of the liver parenchyma without hypointense tumors and vessels was feasible. Gadoxetate-based automatic segmentation of the nontumorous hepatic parenchyma could benefit radioembolization dosimetry and dosimetry-based treatment planning.

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