Abstract #1593
Brown Adipose Tissue Thermometry in the Paraventricular Specific Knock-out Mouse Model at 15.2T
Myriam Diaz Martinez 1 , Henry H Ong 1 , Masoud Ghamari-Langroudi 2 , Aliya Gifford 1,3 , Roger Cone 2 , and E Brian Welch 1
1
Vanderbilt University Institute of Imaging
Science, Vanderbilt University Medical Center,
Nashville, TN, United States,
2
Molecular
Physiology and Biophysics, Vanderbilt University Medical
Center, Nashville, TN, United States,
3
Physical
and Chemical Biology Program, Vanderbilt University
Medical Center, Nashville, TN, United States
Direct and non-invasive measurements of brown adipose
tissues (BAT) temperature is crucial for understanding
its role in thermoregulation in the mouse. We have
implemented a novel fat-water MRI (FWMRI) method with
explicit modeling of temperature which is dependent on
the water frequency offset to estimate the interscapular
BAT temperature at thermoneutral environment in the
Paraventricular (PVN) specific knock-out mouse model, at
ultra high field (15.2T) using the Bruker CryoProbe
surface coil with 2D FLASH sequence, with
multi-interleaved echo count. Our results demonstrate
the potential of MRI to detect subtle changes in
temperature of brown adipose tissue in mice.
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