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Abstract #1640

Expanding the treatment envelope for transcranial MR-guided focused ultrasound with a 256-element clinical transducer

Raag D Airan 1 , Gregory T Clement 2 , Ari Partanen 3 , Martin G Pomper 1 , and Keyvan Farahani 1,4

1 Radiology and Radiological Science, Johns Hopkins Medical Institutions, Baltimore, Maryland, United States, 2 Biomedical Engineering, Cleveland Clinic Lerner Research Institute, Cleveland, Ohio, United States, 3 Clinical Science MR Therapy, Philips Healthcare, Andover, Massachusetts, United States, 4 National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States

MR-guided high intensity focused ultrasound (MR-HIFU) has demonstrated great promise for brain applications. As currently implemented, MR-HIFU has a treatment envelope limited to the center of the brain. We demonstrate in silico that a 256-element non-hemispherical clinical MR-HIFU transducer could develop spatially compact sonication foci transcranially in the brain, at clinically relevant locations in the superficial cortex (superior temporal and inferior frontal gyri) as well as near the skull base (hippocampus, amygdala, nucleus accumbens, BA25, and pons). These results are most relevant for applications requiring lower sonication powers such as blood brain barrier disruption and neuromodulation.

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