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Abstract #1649

In vivo chemical shift-compensated MR thermometry

Pooja Gaur 1,2 , Beat Werner 3 , Pejman Ghanouni 4 , Rachelle Bitton 4 , Kim Butts Pauly 4 , and William A Grissom 2,5

1 Chemical and Physical Biology, Vanderbilt University, Nashville, TN, United States, 2 Institute of Imaging Science, Vanderbilt University, Nashville, TN, United States, 3 Center for MR-Research, University Children's Hospital, Zurich, Switzerland, 4 Radiology, Stanford University, Stanford, CA, United States, 5 Biomedical Engineering, Vanderbilt University, Nashville, TN, United States

MR thermometry measurements used during thermal treatments such as focused ultrasound are subject to heat-induced chemical shift (CS) distortions, which cause errors in images and temperature maps if left uncorrected. A CS-correction method has been previously demonstrated in simulation and phantom studies. In this work, we apply the method to data from clinical sonications in the brain and in soft tissue tumors in the leg. Results show that CS temperature errors can be reliably corrected in patient data, in 0.6 s per map, suggesting that corrections could be performed during the time of treatment.

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