Abstract #1686
Compensating for Stimulated Echoes in Quantitative T2 Relaxometry
Dushyant Kumar 1,2 , Susanne Siemonsen 1,3 , Jens Fiehler 1 , and Jan Sedlacik 1
1
Neuroradiology, Universittsklinikum
Hamburg-Eppendorf, Hamburg, Hamburg, Germany,
2
Multiple
Sclerosis Imaging Section (SeMSI), Universittsklinikum
Hamburg-Eppendorf, Hamburg, Germany, Germany,
3
Multiple
Sclerosis Imaging Section (SeMSI), Universittsklinikum
Hamburg-Eppendorf, Hamburg, Hamburg, Germany
Problem: The voxelwise T2-decay deviate significantly
from multi-exponential (ME) model due to the stimulated
emission (SE) resulting from the imperfect slice profile
of refocusing pulses and the B1-error and so, following
ME model would lead to serious quantification
inaccuracy. Methods: A novel post-processing method,
combining extended phase graph model and
multi-exponential model with nonnegative least-square,
is being proposed to compensate for B1 error. The method
requires using only QT2R data. Results & Conclusions:
Both experimental and simulated results are presented to
demonstrate the improvement. A significant improvement
in myelin quantification is demonstrated when flip angle
error is significant (≥8-10%).
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