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Abstract #1691

Improving Noise Robustness of the Quantitative (q)BOLD Model.

Jan Sedlacik 1 , Dushyant Kumar 1 , and Jens Fiehler 1

1 University Medical Center Hamburg-Eppendorf, Hamburg, Hamburg, Germany

The qBOLD model describes the effect of deoxygenated blood of the capillary network on the signal decay. However, the oxygenation extraction fraction (OEF) and the deoxygenated blood volume (DBV) affect the signal decay very similarly, which allows reliable OEF and DBV estimation only for very high signal to noise ratios (SNR>500). We improved the fitting of the qBOLD model by obscuring the divergent global minimum root mean squared errors (RMSE) by adding noise and finding an effective global minimum by analyzing the local RMSE minima.

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