Oligodendrocytes and the role of iron in magnetic susceptibility driven frequency shifts in white matter

Previous works aimed at describing the relation between susceptibility-driven properties of white matter and the resultant MR signal have relied on models consisting of only hollow cylinders, which simulate axons and their myelin sheaths. While these models benefit from simplicity, they do not capture the full diversity of microstructures present in white matter. Other neuroglia, with their distinct magnetic susceptibilities and volumes, may also have significant influence modulating the MR signal. We demonstrate that the incorporation of iron-rich oligodendrocytes has a significant impact on the underlying frequency distribution and MR signal by virtue of their nontrivial volume fractions and magnetic susceptibility.

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