Abstract #1705

MRI susceptometry measurements of murine brown and white adipose tissue

Henry H. Ong ¹ , Robert A. Horch ^1,2 , John C. Gore ¹ , and E. Brian Welch ¹

¹ Vanderbilt University Institute of Imaging Science, Nashville, TN, United States, ² Radiology and Radiological Sciences, Vanderbilt University, Nashville, TN, United States

Characterization of the magnetic susceptibility ( lower case Greek chi

) of biological tissues may provide insight into their composition and microarchitecture. Despite their biological significance for energy storage and metabolic regulation, there have been few reports of the magnetic properties of white adipose tissue (WAT) and, to the best of our knowledge, none on brown adipose tissue (BAT). For the first time, we report ex vivo MRI susceptometry measurements of murine BAT and WAT. WAT lower case Greek chi

agreed with previous reported values, while BAT lower case Greek chi

was measured to be even more diamagnetic than water. Further study is needed to elucidate the basis of this difference.

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