Improved contrast in multi-echo susceptibility-weighted imaging by using a non-linear echo combination

In this work, a non-linear echo combination approach is introduced to optimize susceptibility contrast in multi-echo SWI. A voxel-wise non-linear combination of magnitude images is introduced prior to calculating SW images. The analytical SNR and CNR of the proposed echo-combination approach are derived and are used to compare the proposed multi-echo approach with the existing single-echo and multi-echo approaches. As shown both experimentally and analytically, the proposed approach provides enhanced susceptibility contrast compared with previous single-echo and multi-echo approaches.

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