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Abstract #1732

Magnetic Susceptibility (QSM) of Thalamic Sub-Nuclear Groups in Multiple Sclerosis

Ferdinand Schweser 1,2 , Devika Rattan 1 , Jesper Hagemeier 1 , Paul Polak 1 , Michael G Dwyer 1 , Christopher R Magnano 1 , and Robert Zivadinov 1,2

1 Buffalo Neuroimaging Analysis Center, Dept. of Neurology, School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, NY, United States, 2 MRI Molecular and Translational Imaging Center, Buffalo CTRC, State University of New York at Buffalo, Buffalo, NY, United States

In this work we investigate for the first time magnetic susceptibility of the thalamic nuclear groups in patients with multiple sclerosis (MS). Visibility of thalamic nuclei on susceptibility maps considerably varied between subjects, with highest visibility in CIS and lowest visibility in SP-MS patients. These results challenge current analysis strategies, which consider basal ganglia nuclei as homogeneous structures. Careful analysis of susceptibility in sub-nuclear groups promises to provide more specific information on pathology-related tissue changes.

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