Abstract #1736
Quantitative susceptibility mapping (QSM) indicates possible iron deficiency in the thalamus and dentate nucleus in restless legs syndrome (RLS)
Xu Li 1,2 , Hongjun Liu 1,2 , Richard P. Allen 3 , Christopher J. Earley 3 , Richard A.E. Edden 1,2 , Peter B. Barker 1,2 , Tiana E. Cruz 3 , and Peter C.M. van Zijl 1,2
1
F.M. Kirby Research Center, Kennedy Krieger
Institute, Baltimore, MD, United States,
2
Radiology,
Johns Hopkins University School of Medicine, Baltimore,
MD, United States,
3
Neurology, Johns Hopkins
University School of Medicine, Baltimore, MD, United
States
Quantitative susceptibility mapping (QSM) at 7T was
utilized to assess brain iron levels in restless legs
syndrome (RLS) (aka Willis Ekbom disease), using the
measured tissue magnetic susceptibility as an iron
index. Data collected on 30 RLS patients and 26
age-matched normal controls showed significantly
decreased magnetic susceptibility in RLS patients as
compared to controls in dentate nucleus and thalamus.
Similar findings were confirmed by a voxel-based
analysis, which suggests that substructures such as the
sub-thalamic nuclei may also be affected by iron
deficiency in RLS.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Click here for more information on becoming a member.
