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Abstract #1736

Quantitative susceptibility mapping (QSM) indicates possible iron deficiency in the thalamus and dentate nucleus in restless legs syndrome (RLS)

Xu Li 1,2 , Hongjun Liu 1,2 , Richard P. Allen 3 , Christopher J. Earley 3 , Richard A.E. Edden 1,2 , Peter B. Barker 1,2 , Tiana E. Cruz 3 , and Peter C.M. van Zijl 1,2

1 F.M. Kirby Research Center, Kennedy Krieger Institute, Baltimore, MD, United States, 2 Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 3 Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, United States

Quantitative susceptibility mapping (QSM) at 7T was utilized to assess brain iron levels in restless legs syndrome (RLS) (aka Willis Ekbom disease), using the measured tissue magnetic susceptibility as an iron index. Data collected on 30 RLS patients and 26 age-matched normal controls showed significantly decreased magnetic susceptibility in RLS patients as compared to controls in dentate nucleus and thalamus. Similar findings were confirmed by a voxel-based analysis, which suggests that substructures such as the sub-thalamic nuclei may also be affected by iron deficiency in RLS.

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