Quantitative susceptibility mapping (QSM) indicates possible iron deficiency in the thalamus and dentate nucleus in restless legs syndrome (RLS)
Xu Li 1,2 , Hongjun Liu 1,2 , Richard P. Allen 3 , Christopher J. Earley 3 , Richard A.E. Edden 1,2 , Peter B. Barker 1,2 , Tiana E. Cruz 3 , and Peter C.M. van Zijl 1,2
F.M. Kirby Research Center, Kennedy Krieger
Institute, Baltimore, MD, United States,
Johns Hopkins University School of Medicine, Baltimore,
MD, United States,
Neurology, Johns Hopkins
University School of Medicine, Baltimore, MD, United
Quantitative susceptibility mapping (QSM) at 7T was
utilized to assess brain iron levels in restless legs
syndrome (RLS) (aka Willis Ekbom disease), using the
measured tissue magnetic susceptibility as an iron
index. Data collected on 30 RLS patients and 26
age-matched normal controls showed significantly
decreased magnetic susceptibility in RLS patients as
compared to controls in dentate nucleus and thalamus.
Similar findings were confirmed by a voxel-based
analysis, which suggests that substructures such as the
sub-thalamic nuclei may also be affected by iron
deficiency in RLS.
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