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Abstract #1752

Retrospective motion correction in CEST MRI data using time domain analysis

Nirbhay N. Yadav 1,2 , Kannie W. Y. Chan 1,2 , Monica Pearl 1 , Piotr Walczak 1 , Miroslaw Janowski 1,3 , Peter C. M. van Zijl 1,2 , and Michael T. McMahon 1,2

1 The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University, Baltimore, MD, United States, 2 FM Kirby Research Center, Kennedy Krieger Institute, Baltimore, MD, United States, 3 NeuroRepair Department, MMRC, PAS, Warsaw, Poland

Abdominal motion has limited the number CEST MRI studies in the body since signal fluctuations can be an order of magnitude larger than the CEST signal. Using simulated data and also data from experiments where arginine capsules where injected into live swine, we show how motion effects in z-spectra can be significantly reduced retrospectively using time-domain analysis.

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