Abstract #1824
High Performance Probe for in vivo Overhauser MRI
David E J Waddington 1,2 , Mathieu Sarracanie 1,3 , Najat Salameh 1,3 , and Matthew S Rosen 1,3
1
MGH/A.A. Martinos Center for Biomedical
Imaging, Charlestown, MA, United States,
2
ARC
Centre of Excellence for Engineered Quantum Systems,
School of Physics, University of Sydney, Sydney, NSW,
Australia,
3
Department
of Physics, Harvard University, Cambridge, MA, United
States
Overhauser-enhanced MRI (OMRI) is an electron-proton
double resonance imaging technique of much interest due
to its ability to detect the concentration and
distribution of free radicals. Tracking of exogenous
free radicals with OMRI in vivo has enabled the
development of oxymetry probes and the imaging of redox
reactions. The large gyromagnetic ratio of electrons (28
GHz/T) demands that in vivo OMRI is performed at very
low magnetic fields (~10 mT) in order to minimize RF
heating and penetration depth issues. We report the
development of a high performance OMRI probe consisting
of a litz wire NMR solenoid (276 kHz) inside a modified
Alderman-Grant Resonator (141 MHz) for operation at 6.5
mT.
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