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Abstract #1824

High Performance Probe for in vivo Overhauser MRI

David E J Waddington 1,2 , Mathieu Sarracanie 1,3 , Najat Salameh 1,3 , and Matthew S Rosen 1,3

1 MGH/A.A. Martinos Center for Biomedical Imaging, Charlestown, MA, United States, 2 ARC Centre of Excellence for Engineered Quantum Systems, School of Physics, University of Sydney, Sydney, NSW, Australia, 3 Department of Physics, Harvard University, Cambridge, MA, United States

Overhauser-enhanced MRI (OMRI) is an electron-proton double resonance imaging technique of much interest due to its ability to detect the concentration and distribution of free radicals. Tracking of exogenous free radicals with OMRI in vivo has enabled the development of oxymetry probes and the imaging of redox reactions. The large gyromagnetic ratio of electrons (28 GHz/T) demands that in vivo OMRI is performed at very low magnetic fields (~10 mT) in order to minimize RF heating and penetration depth issues. We report the development of a high performance OMRI probe consisting of a litz wire NMR solenoid (276 kHz) inside a modified Alderman-Grant Resonator (141 MHz) for operation at 6.5 mT.

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