Abstract #1868
Improved MR thermometry in the presence of non-water proton signals
Jacco A de Zwart 1 , Peter van Gelderen 1 , Qi Duan 1 , Natalia Gudino 1 , Cem M Deniz 2 , Leeor Alon 2 , and Jeff H Duyn 1
1
Advanced MRI, LFMI, NINDS, National
Institutes of Health, Bethesda, MD, United States,
2
Dept.
of Radiology & Sackler Institute of Graduate Biomedical
Sciences, NYU School of Medicine, New York, NY, United
States
A non-linear least squares fitting based method for MR
thermometry is proposed and developed for coil
performance and RF-safety assessment using recently
developed sucrose-doped agarose-water phantoms. The
method, which acquires a minimum of four gradient-echo
signals, allows reliable measurement of
RF-heating-related shifts in water proton resonance
frequency (PRF) in the presence of confounding proton
signals from the doping material. Calibration
experiments show water-PRF temperature dependence of
-0.009 ppmK
-1
for
these agarose-based phantoms, similar to literature
values for tissue (~-0.01 ppmK
-1
). However,
otherwise identical gelatin-based gels show reduced
water-PRF temperature dependence (-0.006 ppmK
-1
),
possibly due to spin exchange.
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