Abstract #1944
The effect of the chemical shift displacement artefact on J-modulation in the STEAM sequence
Carolina Campanha Fernandes 1 , Emma Louise Hall 1 , Chen Chen 1 , Peter Gordon Morris 1 , and Carlos Garrido Salmon 1,2
1
Sir Peter Mansfield Imaging Centre,
University of Nottingham, Nottingham, United Kingdom,
2
Department
of Physics, University of Sao Paulo, Ribeirao Preto,
Brazil
The aim of this study is to derive an analytical model
that takes into account the effects of the chemical
shift displacement artefact (in three dimensions) on
J-modulation of weakly coupled spins in the STEAM
sequence. The signal modulation obtained theoretically
was compared to the one obtained experimentally using a
lactate phantom. This work demonstrated that significant
changes in the coupled-spin response arise due to the
chemical shift displacement artefact, especially at
ultra-high magnetic field strengths. This model provides
a means to predict the resulting lineshapes of
metabolites of AXn form and is a useful tool for
optimization of sequence timing parameters.
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