Abstract #1965
The Influence of Macromolecule Baseline on 1 H Magnetic Resonance Spectroscopic Imaging Reproducibility
Rebecca Birch 1,2 , Andrew C Peet 2,3 , Hamid Dehghani 4 , and Martin Wilson 2,3
1
PSIBS Doctoral Training Centre, University
of Birmingham, Birmingham, West Midlands, United
Kingdom,
2
Department
of Oncology, Birmingham Children's Hospital NHS
Foundation Trust, Birmingham, West Midlands, United
Kingdom,
3
School
of Cancer Sciences, University of Birmingham,
Birmingham, West Midlands, United Kingdom,
4
School
of Computer Science, University of Birmingham,
Birmingham, West Midlands, United Kingdom
Accurate and reproducible MR Spectroscopic Imaging
(MRSI) data is desired. Echo time (TE) is important as a
trade-off between signal and fitting accuracy has to be
established. Macromolecular (MM) signals form a spectral
baseline; which introduces fitting error as signal
overlap occurs with metabolites of interest. MM signals
are predominant in Short TE spectra; therefore a
well-defined MM estimation would be beneficial. The
effect of echo time and experimentally acquired MM
fitting on 2D MRSI reproducibility has been assessed.
TE=80ms was found to be the most reproducible and short
TE accuracy increased with the inclusion of an
experimental acquired baseline.
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