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Abstract #1977

Necessity of tissue volume composition correction for internal referencing

Niklaus Zoelch 1 , Andreas Hock 1,2 , Milan Scheidegger 1,2 , Lea Hulka 2 , Boris Quednow 2,3 , and Anke Henning 1,4

1 Institute for Biomedical Engineering, UZH and ETH Zurich, Zurich, Switzerland, 2 Department of Psychiatry, Psychotherapy and Psychosomatics Hospital of Psychiatry, University of Zurich, Zurich, Switzerland, 3 Zurich Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland, 4 Max Planck Institute for Biological Cybernetics, Tuebingen, Germany

The goal of this work was to investigate absolute quantification of brain metabolites in heterogeneous voxels using internal references. To obtain reliable concentrations in heterogeneous voxels, it is necessary to include corrections for the different concentrations as well as different relaxation properties in grey matter, white matter and cerebrospinal fluid of the reference compound. Absolute concentrations were determined in 18 healthy volunteers either by using the internal water as reference or internal creatine and applying the commonly used corrections. A good agreement between the mean concentrations obtained with both reference standards could be only observed when the commonly used corrections are applied. However the correlation between these concentrations compared to correlation of the simple peak area ratios was decreased.

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