Abstract #1977
Necessity of tissue volume composition correction for internal referencing
Niklaus Zoelch 1 , Andreas Hock 1,2 , Milan Scheidegger 1,2 , Lea Hulka 2 , Boris Quednow 2,3 , and Anke Henning 1,4
1
Institute for Biomedical Engineering, UZH
and ETH Zurich, Zurich, Switzerland,
2
Department
of Psychiatry, Psychotherapy and Psychosomatics Hospital
of Psychiatry, University of Zurich, Zurich,
Switzerland,
3
Zurich
Center for Integrative Human Physiology, University of
Zurich, Zurich, Switzerland,
4
Max
Planck Institute for Biological Cybernetics, Tuebingen,
Germany
The goal of this work was to investigate absolute
quantification of brain metabolites in heterogeneous
voxels using internal references. To obtain reliable
concentrations in heterogeneous voxels, it is necessary
to include corrections for the different concentrations
as well as different relaxation properties in grey
matter, white matter and cerebrospinal fluid of the
reference compound. Absolute concentrations were
determined in 18 healthy volunteers either by using the
internal water as reference or internal creatine and
applying the commonly used corrections. A good agreement
between the mean concentrations obtained with both
reference standards could be only observed when the
commonly used corrections are applied. However the
correlation between these concentrations compared to
correlation of the simple peak area ratios was
decreased.
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