Abstract #2011
Neurometabolic changes observed in the anterior cingulate cortex and the thalamus in schizophrenia and in unipolar mood disorder relative to healthy controls at 7T
Reggie Taylor 1,2 , Betsy Schaefer 3 , Elizabeth Osuch 2,3 , Maria Densmore 2 , Nagalingam Rajakumar 3 , Jean Theberge 1,2 , and Peter Williamson 2,3
1
Medical Biophysics, Western University,
London, ON, Canada,
2
Imaging,
Lawson Health Research Institute, London, ON, Canada,
3
Psychiatry,
Western University, London, ON, Canada
MRS voxels were placed in the anterior cingulate (AC)
and the thalamus (TH) of volunteers with schizophrenia,
volunteers with unipolar mood disorder, and healthy
controls using a 7T MRI. The schizophrenic group and
mood group act as psychiatric controls for each other.
Significant glutamate increases were observed in the AC,
and glutamine increases in the TH, of the schizophrenic
patients relative to controls. Glycine concentrations
were also significantly decreased in the schizophrenic
group relative to both control and mood groups in the
TH. Myo-inositol concentrations were significantly
decreased in both AC and TH relative to the controls and
schizophrenic groups.
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