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Abstract #2011

Neurometabolic changes observed in the anterior cingulate cortex and the thalamus in schizophrenia and in unipolar mood disorder relative to healthy controls at 7T

Reggie Taylor 1,2 , Betsy Schaefer 3 , Elizabeth Osuch 2,3 , Maria Densmore 2 , Nagalingam Rajakumar 3 , Jean Theberge 1,2 , and Peter Williamson 2,3

1 Medical Biophysics, Western University, London, ON, Canada, 2 Imaging, Lawson Health Research Institute, London, ON, Canada, 3 Psychiatry, Western University, London, ON, Canada

MRS voxels were placed in the anterior cingulate (AC) and the thalamus (TH) of volunteers with schizophrenia, volunteers with unipolar mood disorder, and healthy controls using a 7T MRI. The schizophrenic group and mood group act as psychiatric controls for each other. Significant glutamate increases were observed in the AC, and glutamine increases in the TH, of the schizophrenic patients relative to controls. Glycine concentrations were also significantly decreased in the schizophrenic group relative to both control and mood groups in the TH. Myo-inositol concentrations were significantly decreased in both AC and TH relative to the controls and schizophrenic groups.

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