T2 Measurements of Childhood Brain Tumours and Metabolite Concentration Correction
Dominic Carlin 1,2 , Ben Babourina-Brooks 1,2 , Martin Wilson 1,2 , and Andrew C Peet 1,2
School of Cancer Sciences, University of
Birmingham, Birmingham, United Kingdom,
Children's Hospital, Birmingham, United Kingdom
Metabolite concentrations are fundamental prognostic
biomarkers, however measurement is known to be affected
by T2 relaxation. Single-voxel MRS was performed using
PRESS (TR 1500ms, TE 30/135ms) on a 1.5T scanner.
Thirty-three childhood brain tumour patients and
twenty-four healthy controls were analysed using TARQUIN
for metabolite concentrations and T2 relaxation times
were calculated. Concentrations were corrected for
relaxation effects using metabolite and water T2 values
and the importance of accurate T2 values was assessed.
Significant differences in the T2 relaxation of water
were found between tumour and normal brain and between
tumour types which should be accounted for in metabolite
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