Accelerated TE-Averaged Echo-Planar 3D Spectroscopic Imaging: Pilot Validation in Human Brain

This is a pilot demonstration of a novel technique, called accelerated TE-averaged echo-planar Spectroscopic Imaging (accelerated TEA-EPSI), which uses a combination of an echo-planar readout and Compressed Sensing reconstruction to achieve multi-slice TE-averaged spectroscopic images in a clinically feasible time. The data had non-uniform sampling applied along the ky,kz,t1 volume and were reconstructed using minimization of total variation. Afterwards, the data were averaged over the TE increments to obtain TE-averaged spectra. Brain phantom data and in vivo brain spectra show good reproducibility and high spectral quality, demonstrating the potential usefulness of this technique for investigating metabolic changes in different pathologies.

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