Inter-hemispheric Resting State Functional Connectivity in Anesthesia Induced Unconsciousness

The neural mechanism underlying anesthesia-induced unconsciousness (AIU) remains elusive. In this study, we aimed to investigate the system level circuit mechanism of AIU by analyzing the inter-hemispheric resting-state functional connectivity (RSFC) at the awake state and five anesthetic depths. We used pairwise T Test to reveal the connectivity changes from awake state to various anesthesia states, and Pearson correlation to compare the inter-hemispheric RSFC with behavioral data across all AIU states.

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