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Abstract #2047

Whole-brain, sub-second data collection for task-evoked fMRI studies using simultaneous multi-slice/multiband acquisition

Stephanie McMains 1 , R Matthew Hutchison 1,2 , and Ross W Mair 1,3

1 Center for Brain Science, Harvard University, Cambridge, MA, United States, 2 Department of Psychology, Harvard University, Cambridge, MA, United States, 3 AA Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States

We studied visual cortex response at a variety of slice accelerations and TR reductions to investigate the advantages and potential costs for task-based fMRI associated with parameters that allow for whole-brain, sub-second data collection with both block and event-related design paradigms. tstats were significantly higher in the block-design short-TR scans, due to the much larger number of time-points acquired. However, a significant increase is still observed after auto-regressive modeling correction, indicating benefits to block-design experiments from high temporal resolution acquisitions. The observation of higher betas in the event-related design experiment with the short-TR scans is unexpected, and perhaps indicates the hemodynamic response is captured more accurately with the higher temporal resolution.

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