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Abstract #2054

Simultaneous Multislice Acquisition to Avoid Motion Artifacts in Challenging Patient Populations

Andrew S Nencka 1 , Andrew M Huettner 2 , L. Tugan Muftuler 3 , Kevin M. Koch 1 , and Rasmus Birn 4

1 Departments of Biophysics and Radiology, Medical College of Wisconsin, Milwaukee, WI, United States, 2 Department of Biophysics, Medical College of Wisconsin, Milwaukee, WI, United States, 3 Department of Neurosurgery, Medical College of Wisconsin, Milwaukee, WI, United States, 4 Department of Psychiatry, University of Wisconsin, Madison, WI, United States

Simultaneous multislice (SMS) imaging is becoming wide spread in resting state acquisitions following developments from the Human Connectome Project. While most SMS studies are focused upon increasing both spatial and temporal resolution, this study is focused primarily upon increasing volume acquisition time to effectively freeze subject motion. In cases of challenging patient populations, including unsedated children, subject motion can destroy functional connectivity measures. The goal of this work is to acquire the full brain volume as quickly as possible in a resting state acquisition that is expected to be corrupted by motion. In this case, intra-volume motion artifacts can be eliminated. Although full volume coverage with 8mm isotropic voxels can be achieved in 150 ms, data acquired over 390 ms with spatial resolution of 2.6 x 2.6 x 4 mm 3 was found to sufficiently avoid intra-acquisition motion artifacts in the presence of substantial motion. This work offers a new perspective for the application of SMS acquisitions in patient populations.

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