T2 prepared RUFIS: A new imaging paradigm for 3D whole-brain, silent and distortion-free BOLD fMRI

This work presents a novel T2-prepared RUFIS method that tackles two eminent technical challenges of current BOLD fMRI: acoustic noise and geometric distortions. The method was tested and compared with GE-EPI and SE-EPI in healthy volunteers scanned at 3T using a two-segment T2 prepared RUFIS approach in motor and auditory tasks. Additionally, an improved approach using single-shot and further reduced acoustic noise was tested. The method showed a reduction of 40 dB(A) in LAeq acoustic noise measurement with respect to EPI-based methods, lack of geometrical distortions and consistent BOLD response, less sensitive (~1.3% BOLD change) but apparently spatially more specific.

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