Meeting Banner
Abstract #2078

Disrupted Resting State Brain Connectivity in Fetal Complex Congenital Heart Disease

Vincent Kyu Lee 1,2 , Mark DeBrunner 3 , Jennifer A. Johnson 3 , Jodie Votava-Smith 4 , Vidya Rajagopalan 5 , Rafael Ceschin 1,2 , Michelle Gruss 2 , Frederick S. Sherman 3 , and Ashok Panigrahy 1,2

1 Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States, 2 Radiology, Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania, United States, 3 Cardiology, Children's Hospital of Pittsburgh, Pennsylvania, United States, 4 Cardiology, Children's Hospital of Los Angeles, California, United States, 5 Children's Hospital of Los Angeles, Pennsylvania, United States

This is an initial presentation of 3T parallel transmission study on fetal complex congenital heart disease (CHD). ICA analysis was used with resting BOLD of fetal CHD patients to test evidence of disruption in fetal resting state networks (RSN) compared to healthy controls, and whether the degree of disruption of fetal RSN within the complex CHD group is related to the degree of presumed fetal cerebral oxygenation saturation. Our preliminary results provide evidence of disruption of the development of normal RSN in the frontal and posterior regions of the brain in complex CHD fetal cases compared to healthy fetal controls.

This abstract and the presentation materials are available to members only; a login is required.

Join Here