Abstract #2078
Disrupted Resting State Brain Connectivity in Fetal Complex Congenital Heart Disease
Vincent Kyu Lee 1,2 , Mark DeBrunner 3 , Jennifer A. Johnson 3 , Jodie Votava-Smith 4 , Vidya Rajagopalan 5 , Rafael Ceschin 1,2 , Michelle Gruss 2 , Frederick S. Sherman 3 , and Ashok Panigrahy 1,2
1
Radiology, University of Pittsburgh,
Pittsburgh, Pennsylvania, United States,
2
Radiology,
Children's Hospital of Pittsburgh, Pittsburgh,
Pennsylvania, United States,
3
Cardiology,
Children's Hospital of Pittsburgh, Pennsylvania, United
States,
4
Cardiology,
Children's Hospital of Los Angeles, California, United
States,
5
Children's
Hospital of Los Angeles, Pennsylvania, United States
This is an initial presentation of 3T parallel
transmission study on fetal complex congenital heart
disease (CHD). ICA analysis was used with resting BOLD
of fetal CHD patients to test evidence of disruption in
fetal resting state networks (RSN) compared to healthy
controls, and whether the degree of disruption of fetal
RSN within the complex CHD group is related to the
degree of presumed fetal cerebral oxygenation
saturation. Our preliminary results provide evidence of
disruption of the development of normal RSN in the
frontal and posterior regions of the brain in complex
CHD fetal cases compared to healthy fetal controls.
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