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Abstract #2099

Spin-locked Oscillatory Excitation (SLOE): Towards in-vivo Detection of Oscillating Neuronal Currents

Jingwei Sheng 1 , Yuhui Chai 1 , Bing Wu 2 , Weinan Tang 1 , and Jia-Hong Gao 1

1 Center for MRI Research, Peking University, Beijing, Beijing, China, 2 GE Healthcare MR Research China, Beijing, China

We demonstrated the superiority of the spin-locked oscillatory excitation (SLOE) method proposed by our group in detecting sub-nanotelsa oscillatory fields in a phantom study. Furthermore, this sensitivity was verified in anesthetic rats with similar applied oscillatory fields. Our proposed SLOE method showed extremely high detection sensitivity that enables 3T MR scanners for the first time to direct detect applied sub-nT oscillatory magnetic fields both in phantom and rats. The milestone achieved in this work paves the way towards direct mapping neuronal currents by MRI in the study of human brain function.

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