Abstract #2099
Spin-locked Oscillatory Excitation (SLOE): Towards in-vivo Detection of Oscillating Neuronal Currents
Jingwei Sheng 1 , Yuhui Chai 1 , Bing Wu 2 , Weinan Tang 1 , and Jia-Hong Gao 1
1
Center for MRI Research, Peking University,
Beijing, Beijing, China,
2
GE
Healthcare MR Research China, Beijing, China
We demonstrated the superiority of the spin-locked
oscillatory excitation (SLOE) method proposed by our
group in detecting sub-nanotelsa oscillatory fields in a
phantom study. Furthermore, this sensitivity was
verified in anesthetic rats with similar applied
oscillatory fields. Our proposed SLOE method showed
extremely high detection sensitivity that enables 3T MR
scanners for the first time to direct detect applied
sub-nT oscillatory magnetic fields both in phantom and
rats. The milestone achieved in this work paves the way
towards direct mapping neuronal currents by MRI in the
study of human brain function.
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