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Abstract #2103

Mapping effective connectivity in the mouse brain using Granger causality

Md Taufiq Nasseef 1,2 , Adam Liska 1,2 , Stefano Panzeri 1 , and Alessandro Gozzi 1

1 Center for Neuroscience and Cognitive Systems @UniTn, Istituto Italiano di Tecnologia, Rovereto, TN, Italy, 2 Center for Mind/Brain Sciences, University of Trento, Rovereto, TN, Italy

We have recently shown that the mouse brain contains distributed resting-state fMRI (rsfMRI) networks including a putative default-mode like network (DMN). To map the direction of information flow within this network, we have used Granger Causality (GC), a directed measure of functional connectivity, to describe the dominant direction of causation among four key nodes of the mouse DMN. We provide evidence of directional information transfer between nodes of this network that replicate patterns recently described for the human DMN, thus corroborating the presence of an evolutionary conserved DMN precursor in the rodent brain.

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