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Abstract #2107

Contribution of A Brain-state Specific Neurophysiological Event to Large-scale fMRI Signal Fluctuations

Xiao Liu 1 , Toru Yanagawa 2 , David A Leopold 3 , Marieke Schlvinck 4 , Catie Chang 1 , Hiroaki Ishida 5 , Naotaka Fujji 2 , and Jeff H. Duyn 1

1 AMRI, LFMI, NINDS, NIH, Bethesda, MD, United States, 2 BSI, RIKEN, Saitama, Japan, 3 Laboratory of Neuropsychology, NIMH, NIH, Bethesda, MD, United States, 4 Ernst Strngmann Institute for Neuroscience, Frankfurt, Hessen, Germany, 5 Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan

To investigate the neural correlate of large-scale signal fluctuation in resting state fMRI (rsfMRI) and understand its relationship to brain state, we examined the ECoG power recorded from large electrode grids in macaques during eyes-open, eyes-closed wakefulness, and sleep conditions. We observed a brain-state-sensitive, stereotypical event whose spatiotemporal characteristics resembled the rsfMRI characteristics. With an independent dataset of concurrent fMRI-electrophysiology, we further confirmed that the identified events were directly associated with global changes in resting-state fMRI signal.

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