Abstract #2123
Hemodynamic Response Pattern upon Noxious Electrical Stimulation in Rat Models of Pain
Saeedeh Amirmohseni 1 , Daniel Segelcke 2 , Esther Pogatzki-Zahn 2 , and Cornelius Faber 1
1
Department of Clinical Radiology, University
Hospital Muenster, Muenster, Germany,
2
Department
of Anaesthesiology, Intensive Care and Pain Medicine,
University Hospital Muenster, Muenster, Germany
In human fMRI studies, BOLD response to constant painful
electrical and thermal stimulation has shown deviations
from the canonical hemodynamic response function,
leading to possible false negatives in activation maps
when using a boxcar analysis model. In this work, we
have considered possible signal variations during the
BOLD response in the analysis, to process the data of
noxious electrical stimulation of the hindpaw in rat
models of incisional and inflammatory pain, and
demonstrated the importance of accounting for these
variations in order to fit the actual shape of the BOLD
response.
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