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Abstract #2123

Hemodynamic Response Pattern upon Noxious Electrical Stimulation in Rat Models of Pain

Saeedeh Amirmohseni 1 , Daniel Segelcke 2 , Esther Pogatzki-Zahn 2 , and Cornelius Faber 1

1 Department of Clinical Radiology, University Hospital Muenster, Muenster, Germany, 2 Department of Anaesthesiology, Intensive Care and Pain Medicine, University Hospital Muenster, Muenster, Germany

In human fMRI studies, BOLD response to constant painful electrical and thermal stimulation has shown deviations from the canonical hemodynamic response function, leading to possible false negatives in activation maps when using a boxcar analysis model. In this work, we have considered possible signal variations during the BOLD response in the analysis, to process the data of noxious electrical stimulation of the hindpaw in rat models of incisional and inflammatory pain, and demonstrated the importance of accounting for these variations in order to fit the actual shape of the BOLD response.

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