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Abstract #2130

The susceptibility of dissolved oxygen

Avery J.L. Berman 1,2 , Yuhan Ma 1 , Richard D. Hoge 1,3 , and G. Bruce Pike 1,2

1 Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada, 2 Department of Radiology/Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada, 3 Unit de neuroimagerie fonctionelle, Centre de recherche de l'institut de griatrie de Montral, Montreal, Quebec, Canada

The susceptibility of dissolved O 2 in blood was studied, focusing on the implications for BOLD imaging using hyperoxia. We proposed a model for the susceptibility of blood that incorporates dissolved O 2 and compared it with another previously proposed model. Distilled water and samples of bovine plasma were oxygenated and their susceptibilities were determined using gradient echo phase imaging. Measured changes in susceptibility vs. O 2 concentration were linear, with slopes that were dramatically less than previously predicted and in good agreement with our model. Under most physiological conditions, the susceptibility of dissolved O 2 can be disregarded in MRI studies employing hyperoxia.

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