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Abstract #2132

Linear dependence of neuronal oscillations on hypercapnia level: implications for CO 2 calibrated fMRI

Ian D Driver 1 , Joseph Whittaker 1 , Molly G Bright 1 , Suresh D Muthukumaraswamy 1,2 , and Kevin Murphy 1

1 CUBRIC, School of Psychology, Cardiff University, Cardiff, United Kingdom, 2 Schools of Pharmacy and Psychology, Auckland University, Auckland, New Zealand

Understanding the effect of hypercapnia on neuronal oscillations and cerebral metabolism is an important consideration for physiological and calibrated fMRI studies. Here we use MEG measurements to study broadband neuronal desynchronisation during graded levels of hypercapnia. Neuronal desynchronisation persisted even in mild levels of hypercapnia, below the sensory threshold (subjects performed a breathlessness rating task). There appears to be a linear dependence of the neuronal desynchronisation on the level of hypercapnia, presenting a possible solution for hypercapnia calibrated fMRI to overcome the violation of the isometabolic assumption with hypercapnia.

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