Abstract #2132
Linear dependence of neuronal oscillations on hypercapnia level: implications for CO 2 calibrated fMRI
Ian D Driver 1 , Joseph Whittaker 1 , Molly G Bright 1 , Suresh D Muthukumaraswamy 1,2 , and Kevin Murphy 1
1
CUBRIC, School of Psychology, Cardiff
University, Cardiff, United Kingdom,
2
Schools
of Pharmacy and Psychology, Auckland University,
Auckland, New Zealand
Understanding the effect of hypercapnia on neuronal
oscillations and cerebral metabolism is an important
consideration for physiological and calibrated fMRI
studies. Here we use MEG measurements to study broadband
neuronal desynchronisation during graded levels of
hypercapnia. Neuronal desynchronisation persisted even
in mild levels of hypercapnia, below the sensory
threshold (subjects performed a breathlessness rating
task). There appears to be a linear dependence of the
neuronal desynchronisation on the level of hypercapnia,
presenting a possible solution for hypercapnia
calibrated fMRI to overcome the violation of the
isometabolic assumption with hypercapnia.
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