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Abstract #2168

Regional quantifying normal-appearing white matter perfusion in mild to moderate hypertension using 3D pseudo-continous arterial spin labeling

Ting Wang 1 , Yanhua Li 2 , Xinhong Guo 2 , Diandian Huang 1 , Lin Ma 1 , and Xin Lou 1

1 Department of Radiology, Chinese PLA General Hospital, Beijing, Beijing, China, 2 Department of Cardiology, Chinese PLA General Hospital, Beijing, Beijing, China

White matter (WM) is the predilection area of lacunar infarction in hypertensive patients. It was hypothesized that abnormal CBF in WM appeared at early stage of hypertension, hence, we recruited thirty hypertensive patients and thirty healthy controls of an appropriate age to detect their CBF modifications of normal-appearing WM using 3D pcASL technique. As expected, compare to healthy volunteers, CBF values in various WM regions were observed to be lower in hypertensive patients. This proves that 3D pCASL has ability to detect the subtle hemodynamic abnormalities even at the early stage of hypertension.

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