Abstract #2190
Amide proton transfer in detecting intracerebral hemorrhage
Xiaoyue Ma 1 , Panli Zuo 2 , Benjamin Schmitt 3 , Dapeng Shi 4 , Jinyuan Zhou 5 , and Meiyun Wang 4
1
Radiology, Zhengzhou University Peoples
Hospital & Henan Provincial Peoples Hospital,
Zhengzhou, Henan, China,
2
Siemens
Healthcare, MR Collaboration NE Asia, Beijing, China,
3
Siemens
Ltd Australia, Healthcare Sector, Macquarie Park,
Australia,
4
Radiology,
Henan Provincial Peoples Hospital, Zhengzhou, Henan,
China,
5
Radiology,
John Hopkins University, Baltimore, United States
Amide Proton Transfer (APT) is a kind of chemical
exchange-dependent saturation transfer (CEST) imaging
which can detect peptides and endogenous mobile
proteins. We aimed to explore the value of non-invasive
APT in early detecting intracerebral hemorrhage (ICH) at
different stages by comparing it to susceptibility
weighted imaging (SWI), the most sensitive tool for
detecting ICH. Routine MRI, SWI and APT imaging were
performed in 39 patients with ICH at different stages on
a 3.0 T. The MRI findings were evaluated, the signal
values of SWI and APT in the hemorrhage lesions were
measured and compared with the contralateral normal
brain tissue. Paired-sample t-test was used for
statistical evaluation. SWI showed hypointense signal in
15 cases and heterogeneous signal intensity in the other
14 cases. However, all the ICH lesions were hyperintense
on the APT-weighted images. Both the mean values of APT
and SWI were higher in the hemorrhagic lesions than in
the contralateral normal brain tissue (P<0.01). Routine
MR imaging has limitation in detecting ICH because of
the various signal intensities at the different stages.
SWI is more sensitive than conventional MRIs in
detecting ICH. But SWI shows heterogeneous signal
intensity in half of the cases with ICH because of the
T2 and T1 properties in SWI. As APT can detect
endogenous mobile proteins and peptides, the ICH which
contains many hemoglobins always shows hyperintensity on
APT. In this way, APT imaging is sensitive to detect ICH
and may provide a new MRI tool as a routine imaging
technique for early detecting ICH. In this way, APT
imaging is sensitive to detect ICH and may provide a new
MRI tool as a routine imaging technique for early
detecting ICH.
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