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Abstract #2196

High-resolution Neurite Orientation Dispersion and Density Imaging in the substantia nigra of de novo Parkinson disease

Koji Kamagata 1 , Masaaki Hori 1 , Akira Nishikori 2 , Kohei Tsuruta 2 , Ayami Okuzumi 3 , Taku Hatano 3 , Kouhei Kamiya 4 , Nobutaka Hattori 3 , and Shigeki Aoki 1

1 Department of Radiology, Juntendo University, Tokyo, Bunkyo-ku, Japan, 2 Department of Radiological Sciences, Tokyo Metropolitan University, Tokyo, Hachioji-shi, Japan, 3 Department of Neurology, Juntendo University, Tokyo, Bunkyo-ku, Japan, 4 Department of Radiology, the University of Tokyo, Tokyo, Bunkyo-ku, Japan

High-resolution NODDI analysis provides a result that likely reflects a decrease of dendritic length and loss of dendritic spines in the SNpc, consistent with prior pathological research. Because Vic and OD were significantly correlated with disease duration and UPDRS-3, NODDI could become a useful tool for assessing disease progression of PD.

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