Abstract #2196
High-resolution Neurite Orientation Dispersion and Density Imaging in the substantia nigra of de novo Parkinson disease
Koji Kamagata 1 , Masaaki Hori 1 , Akira Nishikori 2 , Kohei Tsuruta 2 , Ayami Okuzumi 3 , Taku Hatano 3 , Kouhei Kamiya 4 , Nobutaka Hattori 3 , and Shigeki Aoki 1
1
Department of Radiology, Juntendo
University, Tokyo, Bunkyo-ku, Japan,
2
Department
of Radiological Sciences, Tokyo Metropolitan University,
Tokyo, Hachioji-shi, Japan,
3
Department of
Neurology, Juntendo University, Tokyo, Bunkyo-ku, Japan,
4
Department
of Radiology, the University of Tokyo, Tokyo, Bunkyo-ku,
Japan
High-resolution NODDI analysis provides a result that
likely reflects a decrease of dendritic length and loss
of dendritic spines in the SNpc, consistent with prior
pathological research. Because Vic and OD were
significantly correlated with disease duration and
UPDRS-3, NODDI could become a useful tool for assessing
disease progression of PD.
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