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Abstract #2251

Characterising the Transition Zone from Tumor to Normal Brain in Glioblastomas using Multimodal MRI

Sarah A Leir 1 , Timothy J Larkin 1,2 , Natalie R Boonzaier 2,3 , Victoria Lupson 2 , Laila A Mohsen 4 , Adam Young 1 , and Stephen J Price 1,3

1 Division of Neurosurgery, Addenbrooke's Hospital, Cambridge, Cambridgeshire, United Kingdom, 2 Wolfson Brain Imaging Centre, Addenbrooke's Hospital, Cambridge, Cambridgeshire, United Kingdom, 3 Department of Clinical Neurosciences, University of Cambridge, Cambridge, Cambridgeshire, United Kingdom, 4 University Department of Radiology, University of Cambridge, Cambridge, Cambridgeshire, United Kingdom

Glioblastomas are one of the most lethal cancers to affect humans. The efficacy of surgical resection and radiotherapy, the mainstays of treatment, is limited by our ability to accurately determine tumor margins. Histological evidence suggests that there is a transition zone from tumor to normal brain extending for several centimeters beyond the T1 enhancing lesion. Diffusion-based MR is a promising new imaging technique to study tumor invasion. Using multimodal MR (DTI, perfusion and spectroscopy), we identify, for the first time, that biomarkers of tumor cell presence extend up to 3 centimeters beyond the conventionally determined and subsequently treated tumor margins.

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