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Abstract #2255

MR-PET based Diagnosis of Gliomas A Prospective Comparison of 3D MRSI and 18 FET PET

Jrg Mauler 1 , Karl-Josef Langen 1 , Andrew A. Maudsley 2 , Omid Nikoubashman 3 , Christian Filss 1 , Gabriele Stoffels 1 , and N. Jon Shah 1

1 Institute of Neuroscience and Medicine, Forschungszentrum Jlich, Jlich, Germany, 2 Miller School of Medicine, University of Miami, FL, United States, 3 Department of Neuroradiology, RWTH Aachen University, Germany

The association of spatially resolved FET uptake and MRS measures was investigated in high- and low-grade gliomas using a hybrid PET-MR scanner. This is intended to increase the sensitivity of the detection of FET negative low-grade tumours in the future. The MR spectral analysis was carried through with respect to choline, N-acetyl-aspartate, myo-inositol and lactate. 9 low-grade and 9 high-grade gliomas showed no clear association between FET uptake und the pattern of altered metabolite levels. Further investigations on a larger number of subjects are required.

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