Abstract #2255
MR-PET based Diagnosis of Gliomas A Prospective Comparison of 3D MRSI and 18 FET PET
Jrg Mauler 1 , Karl-Josef Langen 1 , Andrew A. Maudsley 2 , Omid Nikoubashman 3 , Christian Filss 1 , Gabriele Stoffels 1 , and N. Jon Shah 1
1
Institute of Neuroscience and Medicine,
Forschungszentrum Jlich, Jlich, Germany,
2
Miller
School of Medicine, University of Miami, FL, United
States,
3
Department
of Neuroradiology, RWTH Aachen University, Germany
The association of spatially resolved FET uptake and MRS
measures was investigated in high- and low-grade gliomas
using a hybrid PET-MR scanner. This is intended to
increase the sensitivity of the detection of FET
negative low-grade tumours in the future. The MR
spectral analysis was carried through with respect to
choline, N-acetyl-aspartate, myo-inositol and lactate. 9
low-grade and 9 high-grade gliomas showed no clear
association between FET uptake und the pattern of
altered metabolite levels. Further investigations on a
larger number of subjects are required.
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