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Abstract #2264

Diffusion Tensor Imaging and Pathologic Correlates of Meningiomas

Sumei Wang 1 , Sungheon G Kim 2 , Maria Martinez-Lage 3 , Edward B Lee 3 , Laurie A Loevner 1 , Harish Poptani 1 , John YK Lee 4 , and Suyash Mohan 1

1 Radiology, University of Pennsylvania, Philadelphia, PA, United States, 2 Radiology, New York University School of Medicine, New York, NY, United States, 3 Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, United States, 4 Neurosurgery, University of Pennsylvania, Philadelphia, PA, United States

The purpose of this study was to correlate DTI metrics with the histologic findings including collagen content and Ki-67 labeling index in meningiomas. Forty-five meningiomas underwent DTI studies. High collagen was observed in fibroblastic meningiomas. Atypical meningiomas showed high Ki-67. There was a significant positive correlation between FA and collagen content (r=0.43, p<0.05), and between CP and collagen content (r=0.35, p<0.05). There was a significant negative correlation between MD and Ki67 (r=0.36, p<0.05). DTI can be helpful in predicting tumor consistency and patient outcome.

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