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Abstract #2266

Cranio-spinal radiation produces long term compromise of white matter tracts in childhood brain tumour survivors.

Logan Richard 1,2 , Eric Bouffet 1,2 , Suzanne Laughlin 1 , Normand Laperriere 3 , Kamila Szulc 1 , Douglas Strother 4 , Juliette Hukin 5 , Christopher Fryer 5 , Dina McConnell 5 , Fang Liu 1 , Jovanka Skocic 1 , Alexandra Mogadam 1 , and Donald Mabbott 1,2

1 The Hospital for Sick Children, Toronto, Ontario, Canada, 2 University of Toronto, Toronto, Ontario, Canada, 3 Princess Margaret Hospital, Toronto, Ontario, Canada, 4 University of Calgary, Calgary, Alberta, Canada, 5 British Columbia Children's Hospital, Vancouver, British Columbia, Canada

Investigating the longitudinal effects of cancer therapy on childhood brain tumour survivors is important in understanding their quality of life post-treatment. Our study investigates the effects of brain tumour treatment on several white matter (WM) tracts within the brain of childhood cancer survivors. We used diffusion tensor imaging to delineate specific WM tracts in brain tumour patients treated with different therapies and in healthy children. Survivors treated with craniospinal radiation exhibit compromised WM within multiple tracts including the optic radiation and inferior longitudinal fasciculus. This study provides evidence for the long-term effects of craniospinal radiation on the developing brain.

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